That would not matter in most cases. It can work when a PC is hardwired and the device running the ZCA is wireless. I have also tested it using both 2.4 and 5GHz as well connecting across VLAN/Subnets. I need to test across VPN, but I think it should work if there is a route and communication between the 2 networks is permitted.
So basically, there just needs to be a route and permission for the connection to be made.
I am a network admin.