2022-03 Cumulative Update for Windows 10 Version 20H2 for x64-based Systems (KB5011487)
This Windows 10 update killed mine too. After I System Restored to before that update it resumed functioning. I’m not sure what to do as the hardware is fine, but Zwift and Windows aren’t cooperating. I tried updating FTDI drivers and everything else. There are no problems showing in the Device Manager.