There’s nothing in the NVCP which will transform your performance, certainly not on Makuri Islands which is basically a joke compared to the rest of the game: Game performance on Makuri Islands
That said I’d still expect better than 43fps with your hardware. Are you on max power modes everywhere, not just in the Alienware stuff (which is almost certainly resource-robbing bloatware btw, you should clean install Windows); in Windows power management, and in the Zwift in-game settings? I trust you are running the game whilst plugged into the mains already. On a laptop all of these can have a massive effect on performance. Check it’s not thermal throttling too, that’s another strong possibility on Makuri.
Back to NVCP though, disabling threaded optimisation IMO helps with CPU load (absolutely do not enable it), and enabling triple buffering will allow your system to do say 100fps if it’s capable - by default vsync is dropping you to 50% of your 120Hz refresh rate. Don’t change the actual vsync setting though, you’ll just introduce tearing by turning it off. If you’re happy with 60fps, consider capping the frame rate at 61fps, which reduces the impact of this daft rubber-banding effect: Strange camera behaviour at 60 FPS on PC
Search Facebook for ZPCMR if you want more of this crap. It’s mostly aimed at desktop though, laptops are a poor investment for Zwift.